Sin and departure from God, are the true reasons why people are everywhere laboring and heavy-laden. Sin is the universal disease which infects the whole earth. Sin brought in thorns and thistles at the beginning, and obliged man to earn his bread by the sweat of his brow. Sin is the reason why the “whole creation groans and travails in pain,” and the “foundations of the earth are out of course.” (Rom. 8:22; Psalm 82:5.) Sin is the cause of all the burdens which now press down mankind. Most people know it not, and weary themselves in vain to explain the state of things around them. But sin is the great root and foundation of all sorrow, whatever proud man may think. How much people ought to hate sin!